Formulation: A solid
Formal Name: (3′S)-1′,2′,5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2′-oxo-spiro[6H-cyclopenta[b]pyridine-6,3′-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide
Purity: ≥98%
Formula Markup: C29H23F6N5O3
CAS Number: 1374248-81-3
Notes: Atogepant is an antagonist of the calcitonin gene-related peptide (CGRP) receptor (IC50 = 0.026 nM).{68666} It is selective for the CGRP receptor over the adrenomedullin receptors (AM1) and AM2, calcitonin (CT) receptor, amylin receptor 1 (AMY1), and AMY3 receptor (IC50s = >18,000, 400, 6,274, 2.4 and 1,418 nM, respectively). Atogepant (3-30 mg/kg) increases the mechanical pain threshold in the von Frey test in a rat model of nitroglycerin-induced migraine. Formulations containing atogepant have been used in the prevention of episodic migraines.
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