Formulation: A crystalline solid
Formal Name: 1,3,7-trihydroxy-2,8-dimethoxy-6-methyl-9,10-anthracenedione
Purity: ≥95%
Formula Markup: C17H14O7
Formula Weight: 330,3
Shelf life (days): 1460
CAS Number: 67979-25-3
Notes: Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities.{47459,47460,47461,47462,47463} It inhibits rat lens aldose reductase (RLAR) in vitro (IC50 = 13.6 μM).{47459} Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner.{47460} It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607), ADP, and collagen.{47461} Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS).{47462}
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