Formulation: A solid
Formal Name: N-[(ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide
Purity: ≥98%
Formula Markup: C29H32N4O5S2
Formula Weight: 580,7
Shelf life (days): 1460
CAS Number: 304462-19-9
Notes: AVE-0991 is an agonist of the Mas receptor, also known as the angiotensin (1-7) receptor.{64173} It binds to the Mas receptor in bovine aortic endothelial cell membranes and COS cells (IC50s = 21 and 47.5 nM, respectively).{64172,64173} It reduces urinary volume in water-loaded mice, an effect that can be blocked by the angiotensin (1-7) antagonist A-779 (Item No. 23396) and is reduced in Mas knockout mice.{64173} Dietary administration of AVE-0991 (0.58 µmol/kg per day) inhibits perivascular inflammation and increases plaque stability in an ApoE-/- mouse model of atherosclerosis.{64174} It also inhibits the formation of abdominal aortic aneurysm induced by angiotensin II in ApoE-/- mice.
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