Formulation: A crystalline solid
Formal Name: 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-phenylethyl)-1H-pyrido[4,3-b]indole, monohydrochloride
Purity: ≥98%
Formula Markup: C21H24N2 • HCl
Formula Weight: 340,9
Shelf life (days): 1460
CAS Number: 1061354-48-0
Notes: AVN-101 is a multimodal receptor antagonist.{51394} It is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT7, 5-HT2C, 5-HT2A, and 5-HT6 (Kis = 0.153, 1.17, 1.56, and 2.04 nM, respectively). It is selective for these receptors over 5-HT2B, 5-HT5A, 5-HT1A, and 5-HT1B receptors (Kis = 10.6, 20.8, 61, and 720 nM, respectively). It is also an antagonist of α2A-, α2B-, α2C-, α1B-, α1A-, and α1D-adrenergic receptors (Kis = 0.41, 1.77, 3.55, 9.4, 18.9, and 30.2 nM, respectively), as well as histamine H1 and H2 (Kis = 0.58 and 89 nM, respectively), but not H3, receptors. AVN-101 (0.2, 1, and 5 mg/kg) increases the time spent in the open arms of the elevated plus maze in mice. It also reduces immobility in the forced swim test and prevents scopolamine-induced amnesia in a passive avoidance test in mice when administered at a dose of 0.05 mg/kg.
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