AZ3451, CAS 2100284-59-9

Formulation: A solid

Formal Name: 2-(6-bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide

Purity: ≥98%

Formula Markup: C30H27BrN4O3

Formula Weight: 571,5

Shelf life (days): 1460

CAS Number: 2100284-59-9

Notes: AZ3451 is an allosteric antagonist of proteinase-activated receptor 2 (PAR2) that inhibits calcium mobilization by wild-type and 10 mutant forms of PAR2 induced by the PAR2 ligand SLIGRL in a FLIPR assay (IC50s = 23 and 12-780 nM, respectively).{46658} It is selective for PAR2 over PAR4 and PAR1 (IC50s = 50,000 nM, respectively, in a β-arrestin-2 recruitment assay). AZ3541 completely inhibits SLIGRL-induced phosphorylation of ERK in 1321N1 astrocytoma cells when used at a concentration of 10 µM.

• SKU: CAY29671-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29671-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK