Formulation: A solid
Formal Name: 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-3(2H)-isothiazolone, 1,1-dioxide
Purity: ≥95%
Formula Markup: C24H29N3O3S
Formula Weight: 439,6
Shelf life (days): 1460
CAS Number: 898800-26-5
Notes: AZ876 is a liver X receptor (LXR) agonist.{61503,61504} It activates LXRα and LXRβ in a transactivation assay in U2OS osteosarcoma cells (EC50 = 6 and 73 nM, respectively).{61503} AZ876 reduces phenylephrine-induced increases in cell size and protein synthesis in isolated neonatal rat ventricular myocytes.{61504} It decreases plasma cholesterol and VLDL levels and increases plasma triglyceride and HDL levels, as well as decreases the number and size of aortic root lesions in mice fed a Western diet in an APOE*3-Leiden transgenic mouse model of atherosclerosis when administered at a dose of 20 µmol/kg.{61503}
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