Formulation: A solid
Formal Name: α,α-diphenyl-4-piperidinemethanol
Purity: ≥95%
Formula Markup: C18H21NO
Formula Weight: 267,4
Shelf life (days): 1460
CAS Number: 115-46-8
Notes: Azacyclonol is a CNS depressant.{43955} It reduces transmission through the sympathetic ganglia, decreasing electrically stimulated contractile responses in feline nictitating membrane. It reduces coordinated locomotor activity in mice by greater than 50% when administered at doses of 71, 142, and 213 mg/kg.{43952} Azacyclonol (142 mg/kg) decreases hyperactivity induced by pipradol, D-amphetamine, morphine, and cocaine. It also increases the duration of sleeping time induced by hexobarbital. Azacyclonol is also a metabolite of the histamine H1 receptor antagonist terfenadine (Item No. 20305).{43953,43954} It is formed from terfenadine by the cytochrome P450 (CYP) isoform CYP3A4.{43954}
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