Azatadine (maleate), CAS 3978-86-7

Formulation: A solid

Formal Name: 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, (2Z)-2-butenedioate

Purity: ≥98%

Formula Markup: C20H22N2 • 2C4H4O4

Formula Weight: 522,6

Shelf life (days): 1460

CAS Number: 3978-86-7

Notes: Azatadine is an antihistamine with anticholinergic and antiserotonergic activities.{25628},{52335} It is a histamine H1 receptor antagonist (Ki = 3.9 nM).{52336},{32989} Azatadine inhibits histamine- and acetylcholine-induced contractions in isolated guinea pig ilium and contractions induced by serotonin (5-HT; Item No. 14332) in isolated rat uterus (EC50s = 6.5, 10, and 14 nM, respectively).{52335} It delays the onset of dyspnea induced by aerosolized histamine, 5-HT, or acetylcholine in guinea pigs. Azatadine prevents histamine-induced lethality in guinea pigs and paw edema in mice (ED50s = 9 and 68 μg/kg, respectively).{25628} It increases survival in guinea pig and mouse models of anaphylactic shock with 50% protective dose (PD50) values of 0.024 and 0.019 mg/kg, respectively.{52335}

• SKU: CAY29758-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29758-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK