AZD 1283, CAS 919351-41-0

Formulation: A crystalline solid

Formal Name: 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylic acid, ethyl ester

Purity: ≥98%

Formula Markup: C23H26N4O5S

Formula Weight: 470,5

Shelf life (days): 1460

CAS Number: 919351-41-0

Notes: AZD 1283 is an antagonist of the purinergic P2Y12 receptor (IC50 = 25 nM in a GTPγS assay in CHO cells).{52053} It selectively binds to the P2Y12 receptor (Kd = 11 nM) over more than 100 enzymes, receptors, and ion channels, including the P2Y1, platelet activating factor (PAF), and thromboxane A2 receptors, at 10 µM.{52053},{52054} AZD 1283 increases blood flow and inhibits platelet aggregation induced by ADP in a modified Folts dog model of thrombosis with ED50 values of 3 and 10 µg/kg per minute, respectively.

• SKU: CAY27649-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27649-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK