Formulation: A solid
Formal Name: (2R)-2-[[2-amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol
Purity: ≥98%
Formula Markup: C19H25N5OS2
Formula Weight: 403,6
Shelf life (days): 1460
CAS Number: 911715-90-7
Notes: AZD 8797 is a chemokine (C-X3-C motif) receptor 1 (CX3CR1) antagonist (Ki = 3.9 nM). It is selective for CX3CR1 over CX3CR2 (Ki = 2,800 nM).{50140} AZD 8797 (0.1-10 µM) inhibits [35S]GTPγS accumulation induced by chemokine (C-X3-C) ligand 1 (CX3CL1) in CHO cell membranes expressing human CX3CR1.{50102} It inhibits adhesion of RBMI-8226 cells to CX3CL1 (IC50 = 5.8 nM). AZD 8797 (39 and 78 µmol/kg per day) reduces spinal cord inflammation and demyelination, as well as the incidence of disease relapse, in a rat model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE).{50103}
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