Formulation: A crystalline solid
Formal Name: 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid
Purity: ≥98%
Formula Markup: C25H20N4O5
Formula Weight: 456,5
Shelf life (days): 1460
CAS Number: 147403-03-0
Notes: Azilsartan is an antagonist of the angiotensin II type 1 receptor (AT1; IC50 = 0.42 µM) and the active metabolite of azilsartan medoxomil (Item No. 23805).{52988,36288} Azilsartan is formed from azilsartan medoxomil by hydrolysis in the gastrointestinal tract and liver.{52989} Azilsartan also acts as an inverse agonist, inhibiting angiotensin II-induced accumulation of inositol-1-phosphate in COS-7 cells expressing recombinant human AT1 (IC50 = 2.6 nM).{36288} It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9).{36288} Azilsartan (100 ng/kg, i.v.) inhibits the angiotensin II-induced pressor response in conscious normotensive rats.{52988}
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