B-973B, CAS 2244989-34-0

Formulation: A solid

Formal Name: 3,4-difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]-benzenepropanamide

Purity: ≥98%

Formula Markup: C24H26F2N6O

Formula Weight: 452,5

Shelf life (days): 1460

CAS Number: 2244989-34-0

Notes: B-973B is an allosteric agonist and positive allosteric modulator (ago-PAM) of α7 nicotinic acetylcholine receptors (nAChRs).{66569,66570} It enhances ACh-induced activation in a two-electrode voltage-clamp assay using Xenopus oocytes expressing the human α7 nAChR when used at a concentration of 10 µM.{66570} B-973B (10 mg/kg) decreases paw edema and induces antinociception in the first and second phase of the formalin test in a mouse model of inflammatory pain. It also inhibits tau aggregation induced by seeding with insoluble human tau isolated from a patient with Alzheimer’s disease in primary rat neurons in a concentration-dependent manner.{66571}

• SKU: CAY38790-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38790-10
• Package Unit: 10 mg
• Quantity Unit: STK