Formulation: A lyophilized powder
Formal Name: 3-L-asparagine-22-L-methionine-25-L-serine-α-calcitonin gene-related peptide (human), trifluoroacetate salt
Purity: ≥95%
Formula Markup: C162H267N51O48S3 • XCF3COOH
Formula Weight: 3793,4
Shelf life (days): 1460
Notes: β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.{41395} It belongs to the calcitonin family of peptides, which also includes α-CGRP (Item Nos. 24405 / 24728), amylin (Item No. 24274), calcitonin (Item Nos. 24409 / 24410), and adrenomedullin.{38633} β-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.01 nM) over a complex of CLCR and RAMP2 (IC50 = 300 nM).{41396} It binds to rat brain and spleen membrane preparations (IC50s = 1.1 and 1 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α (PGF2α; Item No. 16010; IC50s = 0.38 and 4.9 nM, respectively).{38809,41528} In vivo, β-CGRP induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 (ET-1; Item No. 24127) in hamster cheek pouch at a concentration of 15.8 pM.{41529}
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