β-Defensin-1 (human) (trifluoroacetate salt)

Formulation: A lyophilized powder

Purity: ≥95%

Formula Markup: C167H256N48O50S6 • XCF3COOH

Formula Weight: 3928,5

Shelf life (days): 1460

Notes: β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.{41472} It inhibits the growth of B. adolescentis, L. acidophilus, B. breve, B. vulgatus, L. fermentum, B. longum, and S. thermophilus in an antimicrobial radial diffusion assay.{40780} β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, including P. gingivalis and S. salivarius, and of susceptible M. tuberculosis H37Rv but not of resistant M. tuberculosis RM22 when used at a concentration of 128 µg/ml.{40781,40782} It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 μM, respectively).{40783} Overexpression of β-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.{40784}

• SKU: CAY24576
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 24576-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK