Formulation: A solid
Formal Name: 4-amino-3-(4-chlorophenyl-2,3,5,6-d4)butanoic acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C10H8ClD4NO2
Formula Weight: 217,7
Shelf life (days): 1460
CAS Number: 1189938-30-4
Notes: (±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen (Item No. 18600) by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
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