BAR502, CAS 1612191-86-2

Formulation: A crystalline solid

Formal Name: (3α,5β,6α,7α)-6-ethyl-24-norcholane-3,7,23-triol

Purity: ≥95%

Formula Markup: C25H44O3

Formula Weight: 392,6

Shelf life (days): 1460

CAS Number: 1612191-86-2

Notes: BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR; EC50s = 0.2 and 1 μM, respectively).{38107} It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter α (OSTα), and small heterodimer partner (SHP) in primary hepatocytes isolated from FXR wild-type mice. BAR502 also increases cAMP-luciferase reporter gene expression, a marker of GP-BAR1 activity, in HEK293T cells.

• SKU: CAY22462-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22462-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK