Formulation: A solid
Formal Name: (4S)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3S)-1-((phenyl-d5)methyl)-3-pyrrolidinyl] ester, monohydrochloride
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C27H24D5N3O6 • HCl
Formula Weight: 533
Shelf life (days): 1460
Notes: Barnidipine-d5 (hydrochloride) is intended for use as an internal standard for the quantification of barnidipine (Item No. 20448) by GC- or LC-MS. Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.{34407} It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.{34406} Formulations containing barnidipine have been used in the treatment of hypertension.
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