Formulation: A solid
Formal Name: 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-4-pyridazinecarboxamide
Purity: ≥98%
Formula Markup: C18H18ClN5O3
CAS Number: 2242464-44-2
Notes: BAY-2416964 is an antagonist of the aryl hydrocarbon receptor (AhR; IC50 = 22 nM in U87 cells).{72306} It decreases the mRNA expression of the AhR target genes CYP1A1 and AHRR induced by the AhR agonist kynurenic acid (Item No. 16792) in LPS-stimulated isolated human monocytes when used at a concentration of 100 nM. BAY-2416964 (30-1,000 nM) increases CD3-, CD28-, and IL-2-induced IFN-γ production in isolated human naïve CD4+ T cells. In vivo, BAY-2416964 (30 mg/kg, p.o.) reduces tumor volume, increases CD8+ T cell and natural killer (NK) cell tumor infiltration, and decreases GR1+ myeloid cell and CD206+ M2 macrophage tumor infiltration in a B16/F10-OVA murine melanoma model.
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