Formulation: A solution in ethanol
Formal Name: 2R-[(4-fluorophenyl)amino]-1R-(trifluoromethyl)-cyclohexanol
Purity: ≥95%
Formula Markup: C13H15F4NO
Formula Weight: 277,3
Shelf life (days): 730
CAS Number: 2741956-55-6
Notes: BAY-390 is an inhibitor of transient receptor potential ankyrin 1 (TRPA1; IC50s = 16 and 63 nM for the human and rat receptor, respectively).{67830} It is selective for TRPA1 over a variety of receptors, ion channels, transporters, and enzymes at 10 µM but weakly inhibits estrogen receptor α (ERα), progesterone receptor B (PR-B), and the dopamine transporter (DAT; IC50s = 5,000, 5,000, and 1,200 nM, respectively). BAY-390 (3-10 mg/kg) reduces the number of flinches and the duration of paw licking in a rat model of nocifensive behavior induced by the TRPA1 agonist cinnamaldehyde and reduces inflammatory pain induced by complete Freund’s adjuvant (CFA) in rats. It also reverses mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation when administered at a dose of 90 mg/kg twice per day.
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