Formulation: A solid
Formal Name: 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy-1,1,2,2-d4]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C30H30D4N2O3
Formula Weight: 474,6
Shelf life (days): 1460
CAS Number: 1133695-49-4
Notes: Bazedoxifene-d4 is intended for use as an internal standard for the quantification of bazedoxifene (Item No. 15005) by GC- or LC-MS. Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM).{22645} Bazedoxifene antagonizes 17β-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as well as hormone-independent growth of MCF-7:5C cells that are resistant to long-term estrogen deprivation (80% reduction with 10 nM).{22646} It has been shown to arrest cell cycling by downregulating cyclin D1 and ERα.
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