Formulation: A solid
Formal Name: (11β,16β)-9-chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
Purity: ≥95%
Formula Markup: C25H33ClO6
Formula Weight: 465
Shelf life (days): 1460
CAS Number: 5534-18-9
Notes: Beclomethasone 17-propionate is a glucocorticoid receptor agonist and an active metabolite of the glucocorticoid prodrug beclomethasone dipropionate (Item No. 38880).{68477,68478} It is formed from beclomethasone dipropionate via esterases and is subsequently hydrolyzed to beclomethasone (Item No. 33196).{68478} Beclomethasone 17-propionate binds to the glucocorticoid receptor (IC50 = 3 nM) and inhibits glucocorticoid receptor transrepression induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), as well as induces transactivation of the glucocorticoid receptor, in CV-1 cells expressing the human receptor in a concentration-dependent manner.{68477} It inhibits LPS-induced increases in IL-6, IL-8, and TNF-α levels in primary human lung macrophages from patients with chronic obstructive pulmonary disease (COPD; IC50s = 0.36, 2.04, and 0.21 nM, respectively).{68479}
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