Formulation: A solid
Formal Name: 9-chloro-11β-hydroxy-16β-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
Purity: ≥98%
Formula Markup: C28H37ClO7
Formula Weight: 521
Shelf life (days): 1460
CAS Number: 5534-09-8
Notes: Beclomethasone dipropionate is a glucocorticoid receptor agonist and prodrug form of beclomethasone 17-propionate (Item No. 38884).{68478,68477} Beclomethasone dipropionate is converted to beclomethasone 17-propionate or beclomethasone 21-propionate via esterases, which are subsequently hydrolyzed to beclomethasone (Item No. 33196).{68478} It binds to the glucocorticoid receptor (IC50 = 2.4 nM) and inhibits glucocorticoid receptor transrepression induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), as well as induces transactivation of the glucocorticoid receptor, in CV-1 cells expressing the human receptor.{68477} Formulations containing beclomethasone dipropionate have been used in the treatment of asthma.
English
Deutsch
