Formulation: A crystalline solid
Formal Name: (4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, monohydrochloride
Purity: ≥98%
Formula Markup: C28H31N3O6 • HCl
Formula Weight: 542
Shelf life (days): 1460
CAS Number: 91599-74-5
Notes: Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels.{34214} In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology.{34216} It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury.{34213,34215,34211} Benidipine is also a competitive antagonist at mineralocorticoid receptors.{34214}
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