Formulation: A solution in ethanol
Formal Name: 4-(butylamino)-benzoic acid, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester
Purity: ≥98%
Formula Markup: C30H53NO11
Formula Weight: 603,8
Shelf life (days): 730
CAS Number: 104-31-4
Notes: Benzonatate is a reversible voltage-gated sodium channel blocker.{37382} It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs.{37383} Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.
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