Formulation: A solid
Formal Name: 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid, monobenzenesulfonate
Purity: ≥95%
Formula Markup: C21H25ClN2O3 • C6H6O3S
Formula Weight: 547,1
Shelf life (days): 1460
CAS Number: 190786-44-8
Notes: Bepotastine is an antagonist of the histamine H1 receptor that is selective over H3, α1-, α2-, and β-adrenergic, dopamine D2long, serotonin 5-HT2, muscarinic acetylcholine, and benzodiazepine receptors.{40405} It reduces dye leakage from the nasal passages of rats acutely sensitized to an antigen (ED50 = 0.03 mg/kg) and inhibits histamine-induced bronchoconstriction in the anesthetized dog (ED50 = 3.2 µg/kg).{40408,40407} Bepotastine prevents conjunctival vascular hyperpermeability in a guinea pig model of conjunctivitis in a dose-dependent manner.{40406} Formulations containing bepotastine have been used in the treatment of itching associated with allergic conjunctivitis.
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