Formulation: A crystalline solid
Formal Name: 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-benzoic acid-d4
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H24D4O2
Formula Weight: 352,5
Shelf life (days): 1460
CAS Number: 2182068-00-2
Notes: Bexarotene-d4 is intended for use as an internal standard for the quantification of bexarotene (Item No. 11571) by GC- or LC-MS. Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50s = 28, 25, and 20 nM for RXRα, β, and γ, respectively).{20758} It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer.{20757,20760} Bexarotene also, through RXR activation, stimulates clearance of soluble β-amyloid, reduces plaque area, and reverses deficits related to Alzheimer’s disease in mice.{20759}
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