Formulation: A crystalline solid
Formal Name: 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
Purity: ≥95%
Formula Markup: C15H13N3O4S
Formula Weight: 331,3
Shelf life (days): 730
CAS Number: 93987-29-2
Notes: Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BI-6015 is a small molecule antagonist of HNF4α that has been shown to repress the expression of known HNF4α target genes.{21357} At concentrations up to 20 μM, BI-6015 has been shown to reduce endogenous insulin gene expression by as much as 50-fold in T6PNE cells.{21357} The hepatocytes from livers of mice injected with 10 and 30 mg/kg BI-6015 exhibit marked, dose-dependent fat accumulation (steatosis).{21357} Additionally, at a daily dose of 30 mg/kg, BI-6015 induces apoptosis in a human hepatocellular carcinoma mouse model.{21357}
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