(−)-Bicuculline methochloride, CAS 53552-05-9

Formulation: A crystalline solid

Formal Name: (5R)-5-[(6S)-6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium, monochloride

Purity: ≥98%

Formula Markup: C21H20NO6 • Cl

Formula Weight: 417,8

Shelf life (days): 1460

CAS Number: 53552-05-9

Notes: (–)-Bicuculline methochloride is an enantiomer of the GABA antagonist (+)-bicuculline methochloride.{45361} It increases the firing rate in rat cortical neurons similar to the (+) isomer but lacks GABA antagonist activity. (–)-Bicuculline methochloride inhibits sodium-independent GABA receptor binding with an IC50 value of 500 μM, which is approximately 100-fold less potent than (+)-bicuculline methochloride, but there is no stereoselectivity for sodium-dependent GABA receptor binding.{45362}

• SKU: CAY27802-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27802-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK