Formulation: A solid
Formal Name: 2,3-dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide, monohydrochloride
Purity: ≥98%
Formula Markup: C19H26N4O2 • HCl
Formula Weight: 378,9
Shelf life (days): 1460
CAS Number: 134296-40-5
Notes: BIMU 8 is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69 nM).{58017} It also binds 5-HT3 receptors (Ki = 0.36 nM). It stimulates cAMP formation in primary mouse embryonic colliculi neurons with an EC50 value of 72 nM.{58018} BIMU 8 (30, 40, and 60 nmol/animal, i.c.v.) induces acetylcholine release in the rat frontal cortex.{58019} It increases postprandial antral and colonic motility in conscious dogs when administered at doses of 0.1, 0.3, and 1 mg/kg.{39019} BIMU 8 (20 mg/kg, i.p.) also increases the latency to withdraw in the paw pressure test in rats.{58020}
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