Formulation: A solid
Formal Name: α-bicyclo[2.2.1]hept-5-en-2-yl-(α-phenyl-d5)-1-piperidinepropanol
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C21H24D5NO
Formula Weight: 316,5
Shelf life (days): 1460
CAS Number: 2938691-75-7
Notes: Biperiden-d5 is intended for use as an internal standard for the quantification of biperiden by GC- or LC-MS. Biperiden is an antagonist of muscarinic acetylcholine receptors (mAChRs; IC50s = 0.48, 6.3, 3.9, 2.4, and 6.3 nM for M1-5 receptors, respectively).{22786} It increases spontaneous and electrically evoked dopamine release and electrically evoked acetylcholine (ACh) release from rabbit caudate nucleus slices preincubated with dopamine.{39395} Biperiden (10 µM) also inhibits NMDA-induced ACh release in rabbit caudate nucleus slices.{39396} Biperiden (0.01-1.0 mg/kg) reduces physostigmine-induced tremor in rats.{39397} Formulations containing biperiden have been used as an adjuvant treatment for Parkinson's disease.
English
Deutsch
