Formulation: A crystalline solid
Formal Name: (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol
Purity: ≥95%
Formula Markup: C10H18O
Formula Weight: 154,3
Shelf life (days): 1460
CAS Number: 464-45-9
Notes: (−)-Borneol is a bicyclic monoterpene originally found in A. canadense.{36773,36774} It is a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors with an EC50 value of 237 µM for human recombinant receptors expressed in X. laevis oocytes.{36773} It increases the latency to first pentylenetetrazole- and maximal electroshock-induced seizure in mice when administered at doses of 50, 100, and 200 mg/kg.{36775} (–)-Borneol (300 mg/kg) also increases the permeability of the blood-brain barrier and increases the concentration of cisplatin reaching tumors in a mouse model of glioblastoma multiforme.{36776} Formulations containing (–)-borneol have been used as fragrance ingredients.
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