Formulation: A crystalline solid
Formal Name: 2,3-dimethoxy-strychnidin-10-one
Purity: ≥98%
Formula Markup: C23H26N2O4
Formula Weight: 394,5
Shelf life (days): 1460
CAS Number: 357-57-3
Notes: Brucine is an alkaloid that has been found in the seeds of the S. nux-vomica tree and has diverse biological activities, including anti-inflammatory, anticancer, and antioxidant properties.{47322} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production induced by LPS in vitro.{47323} Topical administration of brucine decreases synoviocyte proliferation and reduces paw and joint swelling in a rat model of adjuvant-induced arthritis and decreases swelling in a mouse model of xylene-induced ear edema. Brucine (4 and 8 mg/kg per day) reduces tumor incidence, number, and volume in a rat model of mammary gland tumorigenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA).{47322} It prevents decreases in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activity and increases the level of glutathione (GSH) in mammary tissues, as well as reduces markers of lipid peroxidation in plasma and mammary tissue. Brucine also allosterically enhances the effect of low, but not high, concentrations of acetylcholine at M1 muscarinic acetylcholine receptors.{47324}
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