Formulation: A crystalline solid
Formal Name: 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-piperazine, dihydrochloride
Purity: ≥98%
Formula Markup: C28H33ClN2 • 2HCl
Formula Weight: 506
Shelf life (days): 1460
CAS Number: 129-74-8
Notes: Buclizine is an antihistamine.{36933} It reduces bronchoconstriction and lethality induced by aerosolized histamine in guinea pigs when administered at a dose of 1 mg/kg. Buclizine (40-200 mg/kg) induces gross malformations, including fusion of the tongue to the palate, cleft palate, micrognathia, and micromelia, and bone malformations in rats.{36934} It also inhibits cancer cell growth by binding to translationally controlled tumor protein (TCTP) and inducing cell differentiation.{36935} Formulations containing buclizine have been used to treat nausea induced by pregnancy and motion sickness.
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