Bumetanide-d5, CAS 1216739-35-3

Formulation: A solid

Formal Name: 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-d5-benzoic acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C17H15D5N2O5S

Formula Weight: 369,4

Shelf life (days): 1460

CAS Number: 1216739-35-3

Notes: Bumetanide-d5 is intended for use as an internal standard for the quantification of bumetanide (Item No. 14630) by GC- or LC-MS. Bumetanide is an inhibitor of Na-K-2Cl cotransporter 1 (NKCC1; IC50 = 0.68 µM).{60442} It is selective for NKCC1 over NKCC2 (IC50 = 4 µM). Bumetanide is an agonist of G protein-coupled receptor 35 (GPR35; EC50 = 10 µM).{60443} It also inhibits various carbonic anhydrases.{23242} Bumetanide (0.1 mg/kg) increases urine flow and sodium and potassium excretion, as well as decreases sodium reabsorption, in anesthetized dogs.{60444} It reduces brain edema and infarct size in a rat model of stroke induced by permanent middle cerebral artery occlusion (MCAO) when administered at doses ranging from 7.6 to 30.4 mg/kg.{60445} Formulations containing bumetanide have been used in the treatment of edema associated with congestive heart failure and hepatic and renal diseases.

• SKU: CAY26773-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 26773-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung