Formulation: A lyophilized solid
Formal Name: 6-[O-(1,1-dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), hydrazide, 2,2,2-trifluoroacetate
Purity: ≥95%
Formula Markup: C58H83N17O13 • XCF3COOH
Formula Weight: 1226,4
Shelf life (days): 1460
Notes: Buserelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that is at least 20 times more potent than GNRH.{39408,39411} It is a long-acting agent that, after an initial increase in sex hormone levels, decreases the level of circulating gonadotropins and sex hormones.{39411} Buserelin (20 µg/kg) reduces tumor growth in a DMBA-induced rat model of mammary cancer.{39409} It induces enteric neurodegeneration, decreasing the number of luteinizing hormone receptor-positive neurons in the rat gastrointestinal tract, when administered at a dose of 1 mg/kg for 5 days.{39410} Formulations containing buserelin have been used in the treatment of hormone-dependent prostate cancer and endometriosis.
English
Deutsch
