Formulation: A solution in ethanol
Formal Name: 1-O-hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine
Purity: ≥98%
Formula Markup: C28H56NO7P
Formula Weight: 549,7
Shelf life (days): 365
CAS Number: 474944-25-7
Notes: Butenoyl and butanoyl PAF are both products of the oxidative decomposition of 2-arachidonoyl phospholipids.{8533} Oxygenation of C-5 of the 5,6 double bond followed by cleavage of the hydroperoxide results in a PAF-like compound with a 4-carbon residue esterified in the sn-2 position; similar oxidized lipid products also act as ligands for oxidized lipid receptors and peroxisome proliferator-activated receptor.{8953} Although butenoyl PAF is 10-fold less potent than PAF as a PAF receptor agonist, it is present in amounts 100-fold greater than enzymatically generated PAF. Therefore, oxidation of LDL phospholipids generates physiologically relevant bioactive PAF-like molecules.
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