C-178, CAS 329198-87-0

Formulation: A crystalline solid

Formal Name: N-3-dibenzofuranyl-5-nitro-2-furancarboxamide

Purity: ≥98%

Formula Markup: C17H10N2O5

Formula Weight: 322,3

Shelf life (days): 1460

CAS Number: 329198-87-0

Notes: C-178 is a covalent inhibitor of stimulator of interferon genes (STING).{35390} It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 (0.01-1.25 µM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP (Item No. 17144), double-stranded DNA, and LPS when used at a concentration of 0.5 µM.

• SKU: CAY25860-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 25860-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK