C-DIM8, CAS 151358-47-3

Formulation: A solid

Formal Name: 4-(di-1H-indol-3-ylmethyl)-phenol

Purity: ≥95%

Formula Markup: C23H18N2O

Formula Weight: 338,4

Shelf life (days): 1460

CAS Number: 151358-47-3

Notes: C-DIM8 is a para-phenyl-substituted diindolylmethane (C-DIM) and an antagonist of the orphan receptor nuclear receptor-related protein 77 (Nur77).{49136} It inhibits reporter gene expression induced by the Nur77 agonist C-DIM5 (Item No. 27980) in PANC-28 cells when used at a concentration of 20 µM. C-DIM8 (10, 15, and 20 µM) reduces expression of BIRC5, the gene encoding survivin, in PANC-1 pancreatic cancer cells.{57162} In vivo, C-DIM8 (30 mg/kg) induces tumor cell apoptosis and reduces tumor volume in an L3.6pl pancreatic carcinoma mouse xenograft model.

• SKU: CAY30694-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30694-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK