Formulation: A lyophilized powder
Formal Name: glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteine cyclic (6→22)-disulfide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C93H157N27O28S3 • XCF3COOH
Formula Weight: 2197,6
Shelf life (days): 1460
Notes: C-Type natriuretic peptide-22 (CNP-22) is an endogenous peptide with diverse biological activities.{39460,39461,39462} Its 22 amino acid sequence corresponds to residues 105-126 of its precursors prepro CNP, pro CNP, and CNP-53.{39461} CNP-22 is a selective agonist of natriuretic peptide receptors (NPRs) 2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively).{39460} It stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM).{39463,39464} In vivo, CNP-22 (25 μg/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock.{39465}
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