C29, CAS 363600-92-4

Formulation: A crystalline solid

Formal Name: 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid

Purity: ≥95%

Formula Markup: C16H15NO4

Formula Weight: 285,3

Shelf life (days): 1460

CAS Number: 363600-92-4

Notes: C29 is an inhibitor of toll-like receptor 2 (TLR2) signaling.{46288} It inhibits synthetic and bacterial TLR2 agonist-induced TLR2/1 and TLR2/6 signaling in HEK-293T cells expressing human TLR2 (HEK-TLR2) and THP-1 cells when used at a concentration of 50 µM. C29 also inhibits TLR2/1 signaling in primary murine macrophages without inducing cytotoxicity. It decreases the expression of IL-8 induced by the synthetic bacterial lipopeptide TLR2 agonist Pam3CSK4 (Item No. 24126) in HEK-TLR2 cells. C29 (150 µM) inhibits the Pam3CSK4-induced interaction between TLR2 and the adapter protein MyD88, blocks MAPK activation, and decreases NF-κB activation and IκBα degradation in THP-1 cells.

• SKU: CAY27029-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27029-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK