Formulation: A crystalline solid
Formal Name: (1S,3R)-3-[[[4-(6-methyl-2-benzothiazolyl)phenyl]amino]carbonyl]-cyclopentanecarboxylic acid
Purity: ≥98%
Formula Markup: C21H20N2O3S
Formula Weight: 380,5
Shelf life (days): 730
CAS Number: 2415154-29-7
Notes: C3001a is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2.{59302} It increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM, respectively, for the human channels). C3001a is selective for K2P2.1/TREK1 and K2P10.1/TREK2 over a panel of five additional K2P channels at 10 µM. In vivo, C3001a (10 mg/kg) reduces edema and pancreatic necrosis in a mouse model of acute pancreatitis. It reduces mechanical and thermal hyperalgesia in a mouse model of chronic inflammatory pain induced by complete Freund's adjuvant (CFA). C3001a (5 mg/kg) also reduces cold hyperalgesia in a mouse model of neuropathic pain induced by spared nerve injury (SNI).