Formulation: A crystalline solid
Formal Name: 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid
Purity: ≥98%
Formula Markup: C18H21NO4S
Formula Weight: 347,4
Shelf life (days): 1460
CAS Number: 407587-33-1
Notes: CaCC(inh)-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 µM).{37016} CaCC(inh)-A01 (30 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.{34635} CaCC(inh)-A01 also attenuates CaCC TMEM16-A-induced proliferation in cancer cell lines through targeted degradation of the protein and reduces the activity of large-conductance calcium-activated potassium channels (KCa1.1/BK) in human red blood cells.{37017},{37018}
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