Formulation: A crystalline solid
Formal Name: (1R,3S,5Z)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Purity: ≥97%
Formula Markup: C27H44O3
Formula Weight: 416,6
Shelf life (days): 1460
CAS Number: 32222-06-3
Notes: Calcitriol is a vitamin D3 receptor agonist and active metabolite of vitamin D3 (Item No. 11792).{64736,64735} It is formed via a multi-step process, in which vitamin D3 undergoes hydroxylation to 25-hydroxy vitamin D3 (Item No. 9000683) in the liver, followed by further hydroxylation at the 1α-position in the kidney. Calcitriol binds to the vitamin D3 receptor (Kd = 16 pM) and induces differentiation of U937 acute monocytic leukemia cells (EC50 = 2,000 pM).{64738} It induces cell cycle arrest at the S phase and apoptosis in primary adenomatous and hyperplastic human parathyroid cells when used at a concentration of 10 nM.{64734} Calcitriol (0.65 nmol/animal) increases bone calcium mobilization in chicks on a low calcium diet.{64735} It stimulates calcium absorption in the intestines in a chick model of rickets induced by a vitamin D3-deficient diet when administered at a dose of 25 µg/animal.{64736} Formulations containing calcitriol have been used in the treatment of hypocalcemia.
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