Formulation: A crystalline solid
Formal Name: 5H-dibenz[b,f]azepine-5-carboxamide
Purity: ≥98%
Formula Markup: C15H12N2O
Formula Weight: 236,3
Shelf life (days): 1460
CAS Number: 298-46-4
Notes: Carbamazepine is an inhibitor of sodium channels.{16312} It preferentially inhibits inactivated voltage-gated sodium channel Nav1.7 and Nav1.3 (IC50s = 406 and 900 µM, respectively) over resting (closed) Nav1.7 and Nav1.3 channels in whole-cell patch-clamp assays using HEK293 cells (IC50s = 1,584 and 2,464 µM, respectively). Carbamazepine (100 µM) inhibits sodium currents in a rat sciatic nerve patch-clamp assay ex vivo.{66486} It reduces levels of the endogenous catecholamine dopamine in the striatum and hippocampus, as well as the levels of the dopamine precursor L-DOPA (Item No. 13248) in the striatum, in rats when administered at a dose of 100 mg/kg.{66487} Dietary administration of carbamazepine (0.5% w/w) reduces amphetamine-induced hyperactivity in mice.{57511} It decreases immobility time in the forced swim test in mice when administered in the diet at 0.75% w/w. Formulations containing carbamazepine have been used in the treatment of seizures, trigeminal neuralgia, and bipolar disorder.
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