Formulation: A crystalline solid
Formal Name: N-(4-mercapto-1-oxobutyl)-O-methyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide, cyclic (1→5)-thioether, acetate
Purity: ≥98%
Formula Markup: C45H69N11O12S • XC2H4O2
Formula Weight: 988,2
Shelf life (days): 1460
CAS Number: 1631754-28-3
Notes: Carbetocin is an oxytocin receptor agonist and a peptide analog of oxytocin (Item No. 11799).{62008} It selectively binds to oxytocin receptors over vasopressin V2 receptors (Kds = 1.96 and 61.3 nM, respectively). Carbetocin induces contraction of isolated rat uterine strips (EC50 = 48 nM) and inhibits oxytocin-induced contraction of isolated rat uterine strips (pA2 = 8.21). In vivo, carbetocin (0.35 mg/animal) increases the frequency and amplitude of uterine contractions in early postpartum dairy cows.{62009} Carbetocin (6.4 mg/kg, i.p.) prevents stress-induced reinstatement of morphine-seeking behavior in mice.{62010} It also reverses learned helplessness and decreases social withdrawal induced by chronic unpredictable stress in tree shrews.{62011} Formulations containing carbetocin have been used in the prevention of excessive bleeding after childbirth.
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