Formulation: A solid
Formal Name: 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-di(methyl-d3)-ethanamine, (2Z)-2-butenedioate
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C16H13ClD6N2O • C4H4O4
Formula Weight: 412,9
Shelf life (days): 1460
CAS Number: 2747914-08-3
Notes: Carbinoxamine-d6 is intended for use as an internal standard for the quantification of carbinoxamine (Item No. 23937) by GC- or LC-MS. Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine.{23220} It is also an L-type calcium channel inhibitor (Ki = 1.08 nM).{41288} Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively). Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.
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