Formulation: A solid
Formal Name: 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-ethanamine, (2Z)-2-butenedioate
Purity: ≥98%
Formula Markup: C16H19ClN2O • C4H4O4
Formula Weight: 406,9
Shelf life (days): 1460
CAS Number: 3505-38-2
Notes: Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine.{23220} It also competes with [3H]diltiazem, an L-type calcium channel blocker, for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM).{41288} Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM) and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively) by 48% compared with control. Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.
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