Formulation: A crystalline solid
Formal Name: 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-benzeneacetic acid
Purity: ≥98%
Formula Markup: C32H37NO4
Formula Weight: 499,6
Shelf life (days): 1460
CAS Number: 90729-42-3
Notes: Carebastine is an active metabolite of ebastine (Item No. 15372) and a histamine H1 receptor antagonist (Ki = 75.86 nM).{24985,34756,64270} It is formed from ebastine by the cytochrome P450 (CYP) isoform CYP3A4.{34756} Carebastine inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM).{64271} It also inhibits histamine release from isolated rat peritoneal mast cells and human basophils when used at concentrations ranging from 30 to 100 µM. Carebastine decreases production of chemokine (C-C motif) ligand 5 (CCL5) and CCL2 in primary human nasal epithelial cells isolated from patients with nasal allergies.{41052}
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