Formulation: A crystalline solid
Formal Name: 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine, dihydrochloride
Purity: ≥98%
Formula Markup: C27H41N5O2 • 2HCl
Formula Weight: 540,6
Shelf life (days): 1460
CAS Number: 1784252-84-1
Notes: Chemokine (C-C motif) receptor 4 (CCR4) antagonist is an antagonist of CCR4.{38174} It inhibits activation of CCR4 by chemokine (C-C motif) ligand 22 (CCL22) in a [35S]GTPγS assay and also inhibits chemotaxis in human and mouse CCR4-expressing B300-19 cells (IC50s = 18, 140, and 39 nM, respectively). CCR4 antagonist inhibits microglial activation in the cortex in a mouse model of hepatic encephalopathy induced by the neurotoxin azoxymethane when administered at a dose of 1 mg/kg per day.{65368} It reduces azoxymethane-induced increases in Il6 and Il1b expression in mouse cortex. CCR4 antagonist reduces mechanical and thermal sensitivity in a mouse model of type I diabetes induced by streptozotocin (Item No. 13104) when administered intrathecally at doses ranging from 10 to 30 µg/animal.{65367}
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