Formulation: A crystalline solid
Formal Name: 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid
Purity: ≥95%
Formula Markup: C31H41NO4
Formula Weight: 491,7
Shelf life (days): 730
CAS Number: 218600-44-3
Notes: CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM.{6806} By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis.{21759} In various cancer cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis.{21759} Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.{21764,21756,21754}
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